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Cellosaurus Nalm-6-MSH+/TK+/- (CVCL_UD71)

[Text version]

Cell line name Nalm-6-MSH+/TK+/-
Accession CVCL_UD71
Resource Identification Initiative To cite this cell line use: Nalm-6-MSH+/TK+/- (RRID:CVCL_UD71)
Comments Knockout cell: Method=Homologous recombination (1 of 2 alleles); HGNC; 11830; TK1.
Transfected with: HGNC; 7235; MSH2 (exons 9 to 16).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for EGFR p.Arg1068Ter (c.3202C>T) (from parent cell line).
Heterozygous for NRAS p.Ala146Thr (c.436G>A) (from parent cell line).
Heterozygous for RARA p.Gln45Ter (c.133C>T) (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Children:
CVCL_J376 (POLH KO)CVCL_JH01 (POLK CD)CVCL_JH05 (POLK KO)
CVCL_JH00 (POLK KO-CD comp)CVCL_JH07 (POLK KO-comp)CVCL_JG97 (POLK KO-POLH-/-)
CVCL_JH09 (POLZ D2781N)CVCL_JH04 (POLZ L2618F)CVCL_M250 (POLZ L2618M)
CVCL_JH06 (POLZ Y2779F)CVCL_JG99 (POLZ Y2779F-POLH+/-)CVCL_JG98 (POLZ Y2779F-POLK+/-)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=27338670; DOI=10.1016/j.dnarep.2016.06.002
Suzuki T., Gruz P., Honma M., Adachi N., Nohmi T.
Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase zeta to genotoxic stresses.
DNA Repair 45:34-43(2016)

Entry history
Entry creation13-Nov-2018
Last entry updated12-Mar-2020
Version number3