ID   Nalm-6-MSH+/TK+/-
AC   CVCL_UD71
DR   cancercelllines; CVCL_UD71
DR   Wikidata; Q95992056
RX   PubMed=27338670;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 11830; TK1 (Note=1 of 2 alleles).
CC   Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 7325; MSH2 (exons 9 to 16).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0092 ! NALM-6
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 30-01-24; Version: 11
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RX   PubMed=27338670; DOI=10.1016/j.dnarep.2016.06.002;
RA   Suzuki T., Gruz P., Honma M., Adachi N., Nohmi T.;
RT   "Sensitivity of human cells expressing low-fidelity or
RT   weak-catalytic-activity variants of DNA polymerase zeta to genotoxic
RT   stresses.";
RL   DNA Repair 45:34-43(2016).
//