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Cellosaurus LREX' (CVCL_UD76)

[Text version]

Cell line name LREX'
Synonyms LnCaP/AR Resistant to Enzalutamide Xenograft derived
Accession CVCL_UD76
Resource Identification Initiative To cite this cell line use: LREX' (RRID:CVCL_UD76)
Comments Selected for resistance to: ChEBI; CHEBI:68534; Enzalutamide (Xtandi; MDV-3100).
Sequence variations Homozygous for AR p.Thr878Ala (c.2632A>G) (from parent cell line).
Heterozygous for MEN1 p.Tyr313Ter (c.939T>A) (from parent cell line).
Heterozygous for PIK3R1 p.Arg639Ter (c.1915C>T) (from parent cell line).
PTEN p.Lys6Argfs*4 (c.17_18delAA) (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=24315100; DOI=10.1016/j.cell.2013.11.012
Arora V.K., Schenkein E., Murali R., Subudhi S.K., Wongvipat J., Balbas M.D., Shah N., Cai L., Efstathiou E., Logothetis C.J., Zheng D., Sawyers C.L.
Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade.
Cell 155:1309-1322(2013)

Cross-references
Other Wikidata; Q95983040
Entry history
Entry creation13-Nov-2018
Last entry update02-Jul-2020
Version number3