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Cellosaurus DIF2 (CVCL_UF10)

[Text version]
Cell line name DIF2
Accession CVCL_UF10
Resource Identification Initiative To cite this cell line use: DIF2 (RRID:CVCL_UF10)
Comments Population: African; Kenyan.
Characteristics: Moderately resistant to both the antiviral and antiproliferative actions of interferons.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0008 (Daudi)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
Publications

PubMed=6319552; DOI=10.1099/0022-1317-64-12-2649
Tovey M.G., Dron M., Mogensen K.E., Lebleu B., Mechti N., Begon-Lours-Guymarho J.
Isolation of Daudi cells with reduced sensitivity to interferon. II On the mechanisms of resistance.
J. Gen. Virol. 64:2649-2653(1983)

PubMed=6420510; DOI=10.1099/0022-1317-64-12-2641
Dron M., Tovey M.G.
Isolation of Daudi cells with reduced sensitivity to interferon. I Characterization.
J. Gen. Virol. 64:2641-2647(1983)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UF10
Encyclopedic resources Wikidata; Q93527496
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number11