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Cellosaurus DIF3 (CVCL_UF11)

[Text version]

Cell line name DIF3
Accession CVCL_UF11
Resource Identification Initiative To cite this cell line use: DIF3 (RRID:CVCL_UF11)
Comments Characteristics: Strongly resistant to both the antiviral and antiproliferative actions of interferons.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Sequence variations Homozygous for B2M p.Met1Ile (c.3G>C) (from parent cell line).
Homozygous for CTNNB1 p.Ala5_Ala80del (c.14_241del228) (from parent cell line).
TP53 p.Arg213Ter (c.637C>T) (from parent cell line).
Disease Epstein-Barr virus-related Burkitt lymphoma (NCIt: C27694)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0008 (Daudi)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line

PubMed=6319552; DOI=10.1099/0022-1317-64-12-2649
Tovey M.G., Dron M., Mogensen K.E., Lebleu B., Mechti N., Begonlours-Guymarho J.
Isolation of Daudi cells with reduced sensitivity to interferon. II On the mechanisms of resistance.
J. Gen. Virol. 64:2649-2653(1983)

PubMed=6420510; DOI=10.1099/0022-1317-64-12-2641
Dron M., Tovey M.G.
Isolation of Daudi cells with reduced sensitivity to interferon. I Characterization.
J. Gen. Virol. 64:2641-2647(1983)

PubMed=2937878; DOI=10.1099/0022-1317-67-4-663
Dron M., Tovey M.G., Uze G.
Isolation of Daudi cells with reduced sensitivity to interferon. IV Characterization of clones with altered binding of human interferon alpha subspecies.
J. Gen. Virol. 67:663-669(1986)

PubMed=3785169; DOI=10.1128/MCB.6.5.1374
Dron M., Modjtahedi N., Brison O., Tovey M.G.
Interferon modulation of c-myc expression in cloned Daudi cells: relationship to the phenotype of interferon resistance.
Mol. Cell. Biol. 6:1374-1378(1986)

PubMed=8301159; DOI=10.1089/jir.1993.13.377
Dron M., Tovey M.G.
Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-induced increase in ISGF3 gamma content.
J. Interferon Res. 13:377-383(1993)

Entry history
Entry creation13-Nov-2018
Last entry updated24-May-2019
Version number2