ID   DIF3
AC   CVCL_UF11
DR   cancercelllines; CVCL_UF11
DR   Wikidata; Q93527502
RX   PubMed=2937878;
RX   PubMed=3785169;
RX   PubMed=6319552;
RX   PubMed=6420510;
RX   PubMed=8301159;
CC   Population: African; Kenyan.
CC   Characteristics: Strongly resistant to both the antiviral and antiproliferative actions of interferons.
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0008 ! Daudi
SX   Male
AG   16Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 11
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RX   PubMed=2937878; DOI=10.1099/0022-1317-67-4-663;
RA   Dron M., Tovey M.G., Uze G.;
RT   "Isolation of Daudi cells with reduced sensitivity to interferon. IV.
RT   Characterization of clones with altered binding of human interferon
RT   alpha subspecies.";
RL   J. Gen. Virol. 67:663-669(1986).
//
RX   PubMed=3785169; DOI=10.1128/mcb.6.5.1374-1378.1986;
RA   Dron M., Modjtahedi N., Brison O., Tovey M.G.;
RT   "Interferon modulation of c-myc expression in cloned Daudi cells:
RT   relationship to the phenotype of interferon resistance.";
RL   Mol. Cell. Biol. 6:1374-1378(1986).
//
RX   PubMed=6319552; DOI=10.1099/0022-1317-64-12-2649;
RA   Tovey M.G., Dron M., Mogensen K.E., Lebleu B., Mechti N.,
RA   Begon-Lours-Guymarho J.;
RT   "Isolation of Daudi cells with reduced sensitivity to interferon. II.
RT   On the mechanisms of resistance.";
RL   J. Gen. Virol. 64:2649-2653(1983).
//
RX   PubMed=6420510; DOI=10.1099/0022-1317-64-12-2641;
RA   Dron M., Tovey M.G.;
RT   "Isolation of Daudi cells with reduced sensitivity to interferon. I.
RT   Characterization.";
RL   J. Gen. Virol. 64:2641-2647(1983).
//
RX   PubMed=8301159; DOI=10.1089/jir.1993.13.377;
RA   Dron M., Tovey M.G.;
RT   "Interferon-resistant Daudi cells are deficient in
RT   interferon-alpha-induced ISGF3 alpha activation, but remain sensitive
RT   to the interferon-alpha-induced increase in ISGF3 gamma content.";
RL   J. Interferon Res. 13:377-383(1993).
//