| Cell line name |
DIF8 |
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| Accession |
CVCL_UF14 |
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| Resource Identification Initiative |
To cite this cell line use: DIF8 (RRID:CVCL_UF14) |
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| Comments |
Population: African; Kenyan.
Characteristics: Resistant to both the antiviral and antiproliferative actions of interferons.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236. |
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| Sequence variations |
- Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
- Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
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| Disease |
EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0008 (Daudi) |
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| Sex of cell |
Male |
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| Age at sampling |
16Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2580049; DOI=10.1099/0022-1317-66-4-787
Dron M., Tovey M.G., Eid P.
Isolation of Daudi cells with reduced sensitivity to interferon. III Interferon-induced proteins in relation to the phenotype of interferon resistance.
J. Gen. Virol. 66:787-795(1985) PubMed=2937878; DOI=10.1099/0022-1317-67-4-663
Dron M., Tovey M.G., Uze G.
Isolation of Daudi cells with reduced sensitivity to interferon. IV Characterization of clones with altered binding of human interferon alpha subspecies.
J. Gen. Virol. 67:663-669(1986) PubMed=3785169; DOI=10.1128/mcb.6.5.1374-1378.1986
Dron M., Modjtahedi N., Brison O., Tovey M.G.
Interferon modulation of c-myc expression in cloned Daudi cells: relationship to the phenotype of interferon resistance.
Mol. Cell. Biol. 6:1374-1378(1986) PubMed=8301159; DOI=10.1089/jir.1993.13.377
Dron M., Tovey M.G.
Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-induced increase in ISGF3 gamma content.
J. Interferon Res. 13:377-383(1993) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_UF14
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| Encyclopedic resources |
Wikidata; Q93527520
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| Entry history |
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| Entry creation | 13-Nov-2018 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 11 |
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