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Cellosaurus DIF9 (CVCL_UF15)

[Text version]
Cell line name DIF9
Accession CVCL_UF15
Resource Identification Initiative To cite this cell line use: DIF9 (RRID:CVCL_UF15)
Comments Population: African; Kenyan.
Characteristics: Resistant to both the antiviral and antiproliferative actions of interferons.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0008 (Daudi)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
Publications

PubMed=2580049; DOI=10.1099/0022-1317-66-4-787
Dron M., Tovey M.G., Eid P.
Isolation of Daudi cells with reduced sensitivity to interferon. III Interferon-induced proteins in relation to the phenotype of interferon resistance.
J. Gen. Virol. 66:787-795(1985)

PubMed=2937878; DOI=10.1099/0022-1317-67-4-663
Dron M., Tovey M.G., Uze G.
Isolation of Daudi cells with reduced sensitivity to interferon. IV Characterization of clones with altered binding of human interferon alpha subspecies.
J. Gen. Virol. 67:663-669(1986)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UF15
Encyclopedic resources Wikidata; Q93527528
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number11