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Cellosaurus FT246 (CVCL_UH61)

[Text version]
Cell line name FT246
Synonyms iFTSEC246; hTERT FT 246
Accession CVCL_UH61
Resource Identification Initiative To cite this cell line use: FT246 (RRID:CVCL_UH61)
Comments Doubling time: ~32 hours (ATCC=CRL-3448).
Knockout cell: Method=shRNA knockdown; HGNC; 11998; TP53.
Transfected with: HGNC; 1773; CDK4 (with p.Arg24Cys).
Transfected with: HGNC; 11730; TERT.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Derived from site: In situ; Fallopian tube; UBERON=UBERON_0003889.
Cell type: Fallopian tube secretory epithelial cell; CL=CL_4030006.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-3448

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,12
D7S82011
D13S3179,10
D16S5399,13
TH018,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=22936217; DOI=10.1038/nprot.2012.097
Karst A.M., Drapkin R.I.
Primary culture and immortalization of human fallopian tube secretory epithelial cells.
Nat. Protoc. 7:1755-1764(2012)

PubMed=25804953; DOI=10.1093/hmg/ddv101
Coetzee S.G., Shen H.C., Hazelett D.J., Lawrenson K., Kuchenbaecker K., Tyrer J.P., Rhie S.K., Levanon K., Karst A.M., Drapkin R.I., Ramus S.J., Couch F.J., Offit K., Chenevix-Trench G., Monteiro A.N.A., Antoniou A., Freedman M.L., Coetzee G.A., Pharoah P.D.P., Noushmehr H., Gayther S.A.
Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.
Hum. Mol. Genet. 24:3595-3607(2015)

PubMed=26364602; DOI=10.1038/onc.2015.288
Hua G., Lv X., He C., Remmenga S.W., Rodabough K.J., Dong J., Yang L., Lele S.M., Yang P., Zhou J., Karst A.M., Drapkin R.I., Davis J.S., Wang C.
YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.
Oncogene 35:2247-2265(2016)

PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864
Buckley M.A., Woods N.T., Tyrer J.P., Mendoza-Fandino G., Lawrenson K., Hazelett D.J., Najafabadi H.S., Gjyshi A., Carvalho R.S., Lyra P.C. Jr., Coetzee S.G., Shen H.C., Yang A.W., Earp M.A., Yoder S.J., Risch H., Chenevix-Trench G., Ramus S.J., Phelan C.M., Coetzee G.A., Noushmehr H., Hughes T.R., Sellers T.A., Goode E.L., Pharoah P.D.P., Gayther S.A., Monteiro A.N.A.
Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus.
Cancer Res. 79:467-481(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-3448
Encyclopedic resources Wikidata; Q93557163
Gene expression databases GEO; GSM1663016
GEO; GSM1663017
GEO; GSM1663018
GEO; GSM1663019
GEO; GSM1663020
GEO; GSM1663021
GEO; GSM1663022
GEO; GSM1663023
Entry history
Entry creation25-Feb-2019
Last entry update02-May-2024
Version number8