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Cellosaurus ZR-75-1-Dox (CVCL_UJ20)

[Text version]
Cell line name ZR-75-1-Dox
Synonyms Zr-75-1-Dox
Accession CVCL_UJ20
Resource Identification Initiative To cite this cell line use: ZR-75-1-Dox (RRID:CVCL_UJ20)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Poly-ADP-ribosylation by proteomics.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=7902062
de la Torre M., Hao X.-Y., Larsson R., Nygren P., Tsuruo T., Mannervik B., Bergh J.
Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
Anticancer Res. 13:1425-1430(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UJ20
Encyclopedic resources Wikidata; Q98136613
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number8