ID   HCC78-TR
AC   CVCL_UJ33
DR   cancercelllines; CVCL_UJ33
DR   Wikidata; Q93983894
RX   PubMed=24349229;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:91338; 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine (TAE684).
CC   Sequence variation: Gene fusion; HGNC; 10261; ROS1 + HGNC; 11020; SLC34A2; Name(s)=SLC34A2-ROS1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2061 ! HCC78
SX   Male
AG   65Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 05-10-23; Version: 11
//
RX   PubMed=24349229; DOI=10.1371/journal.pone.0082236;
RA   Davies K.D., Mahale S., Astling D.P., Aisner D.L., Le A.T., Hinz T.K.,
RA   Vaishnavi A., Bunn P.A. Jr., Heasley L.E., Tan A.-C., Camidge D.R.,
RA   Varella-Garcia M., Doebele R.C.;
RT   "Resistance to ROS1 inhibition mediated by EGFR pathway activation in
RT   non-small cell lung cancer.";
RL   PLoS ONE 8:E82236-E82236(2013).
//