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Cellosaurus A2780AD (CVCL_UJ39)

[Text version]
Cell line name A2780AD
Synonyms A2780/AD
Accession CVCL_UJ39
Resource Identification Initiative To cite this cell line use: A2780AD (RRID:CVCL_UJ39)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2429947; DOI=10.20772/cancersci1985.77.9_941
Tsuruo T., Hamilton T.C., Louie K.G., Behrens B.C., Young R.C., Ozols R.F.
Collateral susceptibility of adriamycin-, melphalan- and cisplatin-resistant human ovarian tumor cells to bleomycin.
Jpn. J. Cancer Res. 77:941-945(1986)

PubMed=7927910; DOI=10.1002/ijc.2910590118
Huxham I.M., Barlow A.L., Lewis A.D., Plumb J., Mairs R.J., Gaze M.N., Workman P.
Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis.
Int. J. Cancer 59:94-102(1994)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UJ39
Anatomy/cell type resources BTO; BTO:0006326
Encyclopedic resources Wikidata; Q93311635
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number8