ID   SH-SY5Y-TrkB, clone BR6
AC   CVCL_UJ95
SY   SY5Y-TrkB, clone BR6; SH-SY5Y-TrkB, BR6
DR   cancercelllines; CVCL_UJ95
DR   Kerafast; ECP007
DR   Wikidata; Q98132490
RX   PubMed=25684664;
RX   PubMed=26797418;
CC   Population: Caucasian.
CC   Doubling time: 18-24 hours (Kerafast=ECP007).
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
CC   Transfected with: HGNC; 8032; NTRK2.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0019 ! SH-SY5Y
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 05-10-23; Version: 9
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RX   PubMed=25684664; DOI=10.1016/j.canlet.2015.02.011;
RA   Iyer R., Croucher J.L., Chorny M., Mangino J.L., Alferiev I.S.,
RA   Levy R.J., Kolla V., Brodeur G.M.;
RT   "Nanoparticle delivery of an SN38 conjugate is more effective than
RT   irinotecan in a mouse model of neuroblastoma.";
RL   Cancer Lett. 360:205-212(2015).
//
RX   PubMed=26797418; DOI=10.1016/j.canlet.2016.01.018;
RA   Iyer R., Wehrmann L., Golden R.L., Naraparaju K., Croucher J.L.,
RA   MacFarland S.P., Guan P., Kolla V., Wei G., Cam N., Li G., Hornby Z.,
RA   Brodeur G.M.;
RT   "Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a
RT   xenograft mouse model.";
RL   Cancer Lett. 372:179-186(2016).
//