ID   HL-60 SN3
AC   CVCL_UM48
SY   HL-60-SN3; HL60 SN3; HL60/SN3; SN3
DR   cancercelllines; CVCL_UM48
DR   Wikidata; Q94211503
RX   PubMed=8562479;
RX   PubMed=9607592;
CC   Population: Caucasian.
CC   Characteristics: The TP53 null parental cell line was transfected with a wild type TP53 sequence.
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 11998; TP53.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 05-10-23; Version: 10
//
RX   PubMed=8562479;
RA   Banerjee D., Lenz H.-J., Schnieders B., Manno D.J., Ju J.-F.,
RA   Spears C.P., Hochhauser D., Danenberg K.D., Danenberg P.V.,
RA   Bertino J.R.;
RT   "Transfection of wild-type but not mutant p53 induces early monocytic
RT   differentiation in HL60 cells and increases their sensitivity to
RT   stress.";
RL   Cell Growth Differ. 6:1405-1413(1995).
//
RX   PubMed=9607592;
RA   Ju J.-F., Banerjee D., Lenz H.-J., Danenberg K.D., Schmittgen T.C.,
RA   Spears C.P., Schonthal A.H., Manno D.J., Hochhauser D., Bertino J.R.,
RA   Danenberg P.V.;
RT   "Restoration of wild-type p53 activity in p53-null HL-60 cells confers
RT   multidrug sensitivity.";
RL   Clin. Cancer Res. 4:1315-1322(1998).
//