ID   RCC4/empty vector
AC   CVCL_UY81
SY   RCC4 plus vector alone
DR   cancercelllines; CVCL_UY81
DR   Cell_Model_Passport; SIDM01921
DR   ECACC; 03112702
DR   Wikidata; Q98128863
RX   PubMed=10353251;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Ser65Trp (c.194C>G); ClinVar=VCV000043597; Zygosity=Hemizygous (from parent cell line).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): ECACC
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 12
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 8.2
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0498 ! RCC4
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 05-10-23; Version: 8
//
RX   PubMed=10353251; DOI=10.1038/20459;
RA   Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C.,
RA   Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.;
RT   "The tumour suppressor protein VHL targets hypoxia-inducible factors
RT   for oxygen-dependent proteolysis.";
RL   Nature 399:271-275(1999).
//