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Cellosaurus R2F (CVCL_UZ35)

[Text version]
Cell line name R2F
Synonyms R2-F
Accession CVCL_UZ35
Resource Identification Initiative To cite this cell line use: R2F (RRID:CVCL_UZ35)
Comments Senescence: Senesces at 80 PDL (PubMed=12077343).
Derived from site: In situ; Foreskin, skin, dermis; UBERON=UBERON_0001471+UBERON_0002067.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UZ36 (R2F/HTERT)
Sex of cell Male
Age at sampling <1M
Category Finite cell line
Web pages https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=3130603
Tubo R.A., Rheinwald J.G.
Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.
Oncogene Res. 1:407-421(1987)

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002
Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H., De Luca M., Catricala C., O'Toole K.M.
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=19489101; DOI=10.1002/stem.64
Dabelsteen S., Hercule P., Barron P., Rice M., Dorsainville G., Rheinwald J.G.
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cross-references
Encyclopedic resources Wikidata; Q98128779
Entry history
Entry creation25-Feb-2019
Last entry update29-Jun-2023
Version number7