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Cellosaurus Huh7 IFITM2-/- (CVCL_UZ56)

[Text version]

Cell line name Huh7 IFITM2-/-
Accession CVCL_UZ56
Resource Identification Initiative To cite this cell line use: Huh7 IFITM2-/- (RRID:CVCL_UZ56)
Comments Population: Japanese.
Knockout cell: Method=CRISPR/Cas9; HGNC; 5413; IFITM2.
Sequence variations Homozygous for KDR p.Gln472His (c.1416A>T) (from parent cell line).
POLD3 p.Lys70Arg (c.209A>G) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Tyr220Cys (c.659A>G) (ClinVar=VCV000127819) (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=30723923; DOI=10.1002/hep.30548
Shi Y., Du L.-Y., Lv D.-D., Li H., Shang J., Lu J.-J., Zhou L.-Y., Bai L., Tang H.
Exosomal IFITM2 transmitted to DCs inhibits IFNalpha pathway activation and blocks anti-HBV efficacy of exogenous IFNalpha.
Hepatology 69:2396-2413(2019)

Other Wikidata; Q94308822
Entry history
Entry creation25-Feb-2019
Last entry update02-Jul-2020
Version number3