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Cellosaurus RPTC-1 (CVCL_V277)

[Text version]
Cell line name RPTC-1
Accession CVCL_V277
Resource Identification Initiative To cite this cell line use: RPTC-1 (RRID:CVCL_V277)
Comments Problematic cell line: Contaminated. Shown to be a TPC-1 derivative (PubMed=21868764).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00422.
Population: Japanese.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Gene fusion; HGNC; 18782; CCDC6 + HGNC; 9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6298 (TPC-1)
Sex of cell Female
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO11,12
D5S8188,10
D7S82011
D13S31711,12
D16S5399
TH019
TPOX11
vWA14,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Biological sample resources BioSample; SAMN03151973
Encyclopedic resources Wikidata; Q54951283
Entry history
Entry creation16-Apr-2014
Last entry update29-Jun-2023
Version number20