Cellosaurus CCRF-CEM R30/6 (CVCL_V323)

Cell line name CCRF-CEM R30/6
Accession CVCL_V323
Resource Identification Initiative To cite this cell line use: CCRF-CEM R30/6 (RRID:CVCL_V323)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for TP53 p.Arg175His (c.524G>A) and p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_V325 (CCRF-CEM R30dm)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=2450647
Pizzorno G., Mini E., Coronnello M., McGuire J.J., Moroson B.A., Cashmore A.R., Dreyer R.N., Lin J.T., Mazzei T., Periti P., Bertino J.R.
Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.
Cancer Res. 48:2149-2155(1988)

Cross-references
Other Wikidata; Q54809022