Home  |  Contact

Cellosaurus CCRF-CEM R30/6 (CVCL_V323)

Cell line name CCRF-CEM R30/6
Accession CVCL_V323
Resource Identification Initiative To cite this cell line use: CCRF-CEM R30/6 (RRID:CVCL_V323)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for TP53 p.Arg175His (c.524G>A) and p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
CVCL_V325 (CCRF-CEM R30dm)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line

Pizzorno G., Mini E., Coronnello M., McGuire J.J., Moroson B.A., Cashmore A.R., Dreyer R.N., Lin J.T., Mazzei T., Periti P., Bertino J.R.
Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.
Cancer Res. 48:2149-2155(1988)

Other Wikidata; Q54809022