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Cellosaurus CCRF-CEM R30dm (CVCL_V325)

Cell line name CCRF-CEM R30dm
Synonyms R30dm-CCRF-CEM; R30dm
Accession CVCL_V325
Resource Identification Initiative To cite this cell line use: CCRF-CEM R30dm (RRID:CVCL_V325)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for TP53 p.Arg175His (c.524G>A) and p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V323 (CCRF-CEM R30/6)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line

McCloskey D.E., McGuire J.J., Russell C.A., Rowan B.G., Bertino J.R., Pizzorno G., Mini E.
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
J. Biol. Chem. 266:6181-6187(1991)

Chemistry resources ChEMBL-Cells; CHEMBL3307546
ChEMBL-Targets; CHEMBL614143
Other Wikidata; Q54809023