Due to maintenance work, this service will suffer intermittent downtimes on Tuesday February 20th between 12.00 pm and 2.00 pm CEST.

Cellosaurus CCRF-CEM R30dm (CVCL_V325)

Cell line name CCRF-CEM R30dm
Synonyms R30dm-CCRF-CEM; R30dm
Accession CVCL_V325
Resource Identification Initiative To cite this cell line use: CCRF-CEM R30dm (RRID:CVCL_V325)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Sequence variation: Heterozygous for FLT3 p.Ala627Thr (from parent cell line).
Sequence variation: Heterozygous for KRAS p.Gly12Asp (from parent cell line).
Sequence variation: Heterozygous for TP53 p.Arg175His and p.Arg248Gln (from parent cell line).
Derived from sampling site: Peripheral blood.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V323 (CCRF-CEM R30/6)
Sex of cell Female
Category Cancer cell line

McCloskey D.E., McGuire J.J., Russell C.A., Rowan B.G., Bertino J.R., Pizzorno G., Mini E.
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
J. Biol. Chem. 266:6181-6187(1991)

Chemistry resources ChEMBL-Cells; CHEMBL3307546
ChEMBL-Targets; CHEMBL614143