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Cellosaurus MCF7 Tet-On (CVCL_V332)

[Text version]
Cell line name MCF7 Tet-On
Synonyms MCF7 Tet On; MCF-7 Tet-On
Accession CVCL_V332
Resource Identification Initiative To cite this cell line use: MCF7 Tet-On (RRID:CVCL_V332)
Comments Population: Caucasian.
Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
Discontinued: Takara/Clontech; Catalog number 630918.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_JX63 (MCF7EL)CVCL_JX64 (MCF7T1)CVCL_JX65 (MCF7T2)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_V332
Encyclopedic resources Wikidata; Q54904453
Entry history
Entry creation16-Apr-2014
Last entry update30-Jan-2024
Version number17