Cellosaurus LoVo-MEK-R (CVCL_V402)

Cell line name LoVo-MEK-R
Accession CVCL_V402
Resource Identification Initiative To cite this cell line use: LoVo-MEK-R (RRID:CVCL_V402)
Comments Selected for resistance to: ChEBI; CHEBI:88249; 391210-10-9 (PD0325901).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0399 (LoVo)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line

PubMed=22402123; DOI=10.1158/1535-7163.MCT-11-1010
Hatzivassiliou G., Liu B., O'Brien C., Spoerke J.M., Hoeflich K.P., Haverty P.M., Soriano R., Forrest W.F., Heldens S., Chen H., Toy K., Ha C., Zhou W., Song K., Friedman L.S., Amler L.C., Hampton G.M., Moffat J., Belvin M., Lackner M.R.
ERK inhibition overcomes acquired resistance to MEK inhibitors.
Mol. Cancer Ther. 11:1143-1154(2012)

Polymorphism and mutation databases Cosmic; 1927245