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Cellosaurus SLR20 (CVCL_V606)

[Text version]

Cell line name SLR20
Synonyms SLR 20
Accession CVCL_V606
Resource Identification Initiative To cite this cell line use: SLR20 (RRID:CVCL_V606)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (ICLAC). Originally thought to originate from a clear cell renal cell carcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 24 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Miscellaneous: STR profile from personal communication of von Teichman A.
Sequence variations Homozygous for HRAS p.Gly12Val (c.35G>T) (CCLE).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Tyr126Ter (c.378C>G) (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.52
East Asian, North2.35
East Asian, South0
South Asian0
European, North72.79
European, South24.34
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Children:
CVCL_UY80 (SLR20.A2)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,12
D5S81810,12
D7S82010,11
D13S31712
D16S5399
D21S1129
TH016
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=12907621
Tatsumi T., Herrem C.J., Olson W.C., Finke J.H., Bukowski R.M., Kinch M.S., Ranieri E., Storkus W.J.
Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma.
Cancer Res. 63:4481-4489(2003)

PubMed=19470766; DOI=10.1158/0008-5472.CAN-09-0146
Beroukhim R., Brunet J.-P., Di Napoli A., Mertz K.D., Seeley A., Pires M.M., Linhart D., Worrell R.A., Moch H., Rubin M.A., Sellers W.R., Meyerson M., Linehan W.M., Kaelin W.G. Jr., Signoretti S.
Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer Res. 69:4674-4681(2009)

PubMed=19690146; DOI=10.1158/0008-5472.CAN-08-4511
Kawabe M., Mandic M., Taylor J.L., Vasquez C.A., Wesa A.K., Neckers L.M., Storkus W.J.
Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17- demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.
Cancer Res. 69:6995-7003(2009)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; SLR20_KIDNEY
Cell_Model_Passport; SIDM01341
DepMap; ACH-000127
Biological sample resources BioSample; SAMN10988419
Chemistry resources PharmacoDB; SLR20_1421_2019
Gene expression databases GEO; GSM374467
Other Wikidata; Q54954870
Entry history
Entry creation16-Apr-2014
Last entry updated06-Sep-2019
Version number10