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Cellosaurus SLR21 (CVCL_V607)

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Cell line name SLR21
Synonyms SLR 21
Accession CVCL_V607
Resource Identification Initiative To cite this cell line use: SLR21 (RRID:CVCL_V607)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 60 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Miscellaneous: STR profile from personal communication of von Teichman A.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.09
Native American0.64
East Asian, North0
East Asian, South0.43
South Asian1.26
European, North66.35
European, South31.24
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Derived from metastatic site: Not specified.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11,13
D3S135814,16
D5S81812,13
D7S82010,11
D8S11798,15
D13S31712,14
D16S53910,12
D18S5113,16
D21S1128,29
FGA23
Penta D9,10
Penta E7,14
TH019.3
TPOX8
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=12907621
Tatsumi T., Herrem C.J., Olson W.C., Finke J.H., Bukowski R.M., Kinch M.S., Ranieri E., Storkus W.J.
Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma.
Cancer Res. 63:4481-4489(2003)

PubMed=19470766; DOI=10.1158/0008-5472.CAN-09-0146
Beroukhim R., Brunet J.-P., Di Napoli A., Mertz K.D., Seeley A., Pires M.M., Linhart D., Worrell R.A., Moch H., Rubin M.A., Sellers W.R., Meyerson M., Linehan W.M., Kaelin W.G. Jr., Signoretti S.
Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer Res. 69:4674-4681(2009)

PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; SLR21_KIDNEY
DepMap; ACH-000016
Biological sample resources BioSample; SAMN10988415
Chemistry resources PharmacoDB; SLR21_1422_2019
Gene expression databases GEO; GSM374468
Other Wikidata; Q54954872
Polymorphism and mutation databases Cosmic; 2520630
Entry history
Entry creation16-Apr-2014
Last entry updated06-Sep-2019
Version number10