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Cellosaurus SLR24 (CVCL_V610)

[Text version]

Cell line name SLR24
Synonyms SLR 24
Accession CVCL_V610
Resource Identification Initiative To cite this cell line use: SLR24 (RRID:CVCL_V610)
Comments Problematic cell line: Contaminated. Shown to be a RCC4 derivative (ICLAC).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 30 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Miscellaneous: STR profile from personal communication of von Teichman A.
Sequence variations Hemizygous for VHL p.Ser65Trp (c.194C>G) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.24
Native American0
East Asian, North2.8
East Asian, South0
South Asian0
European, North55.96
European, South41
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0498 (RCC4)
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S8208
D13S31711,12
D16S53911
D21S1130
TH019.3
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=12907621
Tatsumi T., Herrem C.J., Olson W.C., Finke J.H., Bukowski R.M., Kinch M.S., Ranieri E., Storkus W.J.
Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma.
Cancer Res. 63:4481-4489(2003)

PubMed=19470766; DOI=10.1158/0008-5472.CAN-09-0146
Beroukhim R., Brunet J.-P., Di Napoli A., Mertz K.D., Seeley A., Pires M.M., Linhart D., Worrell R.A., Moch H., Rubin M.A., Sellers W.R., Meyerson M., Linehan W.M., Kaelin W.G. Jr., Signoretti S.
Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer Res. 69:4674-4681(2009)

PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; SLR24_KIDNEY
Cell_Model_Passport; SIDM01339
DepMap; ACH-000272
Biological sample resources BioSample; SAMN10988394
Chemistry resources PharmacoDB; SLR24_1424_2019
Gene expression databases GEO; GSM374471
Other Wikidata; Q54954875
Polymorphism and mutation databases Cosmic; 2520643
Entry history
Entry creation16-Apr-2014
Last entry updated06-Sep-2019
Version number9