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Cellosaurus F5 (CVCL_V616)

Cell line name F5
Accession CVCL_V616
Resource Identification Initiative To cite this cell line use: F5 (RRID:CVCL_V616)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 46 hours (PubMed=25984343); 1 day (PubMed=34850056).
Omics: Deep exome analysis.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.76
Native American0
East Asian, North3.58
East Asian, South0
South Asian0
European, North60.4
European, South33.25
Disease Meningioma (NCIt: C3230)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=7542695; DOI=10.1007/BF01058456
Yazaki T., Takamiya Y., Costello P.C., Mineta T., Menon A.G., Rabkin S.D., Martuza R.L.
Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470.
J. Neurooncol. 23:23-29(1995)

PubMed=7585498
Yazaki T., Manz H.J., Rabkin S.D., Martuza R.L.
Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.
Cancer Res. 55:4752-4756(1995)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=34850056; DOI=10.1093/jnen/nlab111
Uhlmann E.J., Rabinovsky R., Varma H., El Fatimy R., Kasper E.M., Moore J.M., Vega R.A., Thomas A.J., Alterman R.L., Stippler M., Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.
Tumor-derived cell culture model for the investigation of meningioma biology.
J. Neuropathol. Exp. Neurol. 80:1117-1124(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V616
Cell_Model_Passport; SIDM01497
DepMap; ACH-001067
Anatomy/cell type resources BTO; BTO:0004530
CRISP screens repositories BioGRID_ORCS_Cell_line; 434
Chemistry resources PharmacoDB; F5_364_2019
Encyclopedic resources Wikidata; Q54833148
Polymorphism and mutation databases Progenetix; CVCL_V616
Entry history
Entry creation16-Apr-2014
Last entry update30-Jan-2024
Version number16