Home  |  Contact

Cellosaurus HCC827 GR5 (CVCL_V622)

[Text version]

Cell line name HCC827 GR5
Synonyms HCC827-GR5; HCC-827-GR5; HCC827GR5
Accession CVCL_V622
Resource Identification Initiative To cite this cell line use: HCC827 GR5 (RRID:CVCL_V622)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 48 hours (PubMed=25984343).
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Sequence variations Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=17463250; DOI=10.1126/science.1141478
Engelman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C., Park J.O., Lindeman N.I., Gale C.M., Zhao X., Christensen J.G., Kosaka T., Holmes A.J., Rogers A.M., Cappuzzo F., Mok T., Lee C., Johnson B.E., Cantley L.C., Janne P.A.
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Science 316:1039-1043(2007)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; HCC827GR5_LUNG
Cell_Model_Passport; SIDM01636
DepMap; ACH-000029
Biological sample resources BioSample; SAMN10988418
Chemistry resources PharmacoDB; HCC827GR5_462_2019
Gene expression databases GEO; GSM466322
Other Wikidata; Q54881790
Polymorphism and mutation databases Progenetix; CVCL_V622
Entry history
Entry creation16-Apr-2014
Last entry update20-May-2021
Version number14