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Cellosaurus HCC827 GR6 (CVCL_V623)

[Text version]
Cell line name HCC827 GR6
Accession CVCL_V623
Resource Identification Initiative To cite this cell line use: HCC827 GR6 (RRID:CVCL_V623)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO11
D3S135817
D5S81812
D7S82011,12
D8S117912
D13S3179
D16S53912
D18S5113
D21S1131
FGA24
Penta D14
Penta E19,20
TH016
TPOX8
vWA18

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Publications

PubMed=17463250; DOI=10.1126/science.1141478
Engelman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C., Park J.O., Lindeman N.I., Gale C.-M., Zhao X.-J., Christensen J.G., Kosaka T., Holmes A.J., Rogers A.M., Cappuzzo F., Mok T., Lee C., Johnson B.E., Cantley L.C., Janne P.A.
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Science 316:1039-1043(2007)

Cross-references
Cell line collections (Providers) Millipore; SCC426
Cell line databases/resources cancercelllines; CVCL_V623
Encyclopedic resources Wikidata; Q54881791
Gene expression databases GEO; GSM466323
Polymorphism and mutation databases Progenetix; CVCL_V623
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number17