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Cellosaurus OPM-2/BR (CVCL_VJ35)
[Text version]
Cell line name |
OPM-2/BR
|
Synonyms |
OPM2/BR
|
Accession |
CVCL_VJ35
|
Resource Identification Initiative |
To cite this cell line use: OPM-2/BR (RRID:CVCL_VJ35) |
Comments |
Population: Japanese. Characteristics: Produces Ig lambda. Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade). Derived from sampling site: Peripheral blood.
|
Sequence variations |
- Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3690; FGFR3; Simple; p.Lys650Glu (c.1948A>G); ClinVar=VCV000016331; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6768; SMAD2; Simple; p.Leu87Arg (c.260T>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
|
Disease |
Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
|
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606)
|
Hierarchy |
Parent: CVCL_1625 (OPM-2)
|
Sex of cell |
Female
|
Age at sampling |
56Y
|
Category |
Cancer cell line
|
Publications | PubMed=25382610; DOI=10.1038/bcj.2014.74 Chitta K.S., Paulus A., Caulfield T.R., Akhtar S., Blake M.-K.K., Ailawadhi S., Knight J., Heckman M.G., Pinkerton A., Chanan-Khan A.A. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia. Blood Cancer J. 4:e260.1-e260.10(2014) |
Cross-references |
Encyclopedic resources |
Wikidata; Q98128352
|
Entry history |
Entry creation | 07-Sep-2018 |
Last entry update | 20-May-2021 |
Version number | 6 |
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