ID   OPM-2/BR
AC   CVCL_VJ35
SY   OPM2/BR
DR   cancercelllines; CVCL_VJ35
DR   Wikidata; Q98128352
RX   PubMed=25382610;
CC   Population: Japanese.
CC   Characteristics: Produces Ig lambda.
CC   Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3690; FGFR3; Simple; p.Lys650Glu (c.1948A>G); ClinVar=VCV000016331; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6768; SMAD2; Simple; p.Leu87Arg (c.260T>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1625 ! OPM-2
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 05-10-23; Version: 9
//
RX   PubMed=25382610; DOI=10.1038/bcj.2014.74;
RA   Chitta K.S., Paulus A., Caulfield T.R., Akhtar S., Blake M.-K.K.,
RA   Ailawadhi S., Knight J., Heckman M.G., Pinkerton A., Chanan-Khan A.A.;
RT   "Nimbolide targets BCL2 and induces apoptosis in preclinical models of
RT   Waldenstroms macroglobulinemia.";
RL   Blood Cancer J. 4:e260.1-e260.10(2014).
//