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Cellosaurus SCCIC19 (CVCL_VJ53)

[Text version]
Cell line name SCCIC19
Synonyms SCC IC19; IC9
Accession CVCL_VJ53
Resource Identification Initiative To cite this cell line use: SCCIC19 (RRID:CVCL_VJ53)
Comments Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Scalp, skin; UBERON=UBERON_8300000.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.151-1G>A; ClinVar=VCV000635365; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=24662767).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Cys254Arg (c.760T>C); ClinVar=VCV002130225; Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Trp1843Ter (c.5528G>A); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 7882; NOTCH2; Simple; p.Cys315Ter (c.945T>A); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro64Leu (c.191C>T); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly199Glu (c.596G>A); ClinVar=VCV000582257; Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Leu (c.833C>T); ClinVar=VCV000232497; Zygosity=Unspecified (PubMed=24662767).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 81Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX
CSF1PO11
D2S133819,21
D3S135815
D5S81812
D7S8209,12
D8S117913,15
D13S31710,12
D16S5399,12
D18S5111,18
D19S43313.1,15.2
D21S1132.2
FGA20,22
TH016,7
TPOX11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=24662767; DOI=10.1038/jid.2014.154
South A.P., Purdie K.J., Watt S.A., Haldenby S., den Breems N.Y., Dimon M., Arron S.T., Kluk M.J., Aster J.C., McHugh A., Xue D.J., Dayal J.H.S., Robinson K.S., Rizvi S.M.H., Proby C.M., Harwood C.A., Leigh I.M.
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.
J. Invest. Dermatol. 134:2630-2638(2014)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1
Inman G.J., Wang J., Nagano A., Alexandrov L.B., Purdie K.J., Taylor R.G., Sherwood V., Thomson J., Hogan S., Spender L.C., South A.P., Stratton M.R., Chelala C., Harwood C.A., Proby C.M., Leigh I.M.
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428
Hassan S., Purdie K.J., Wang J., Harwood C.A., Proby C.M., Pourreyron C., Mladkova N., Nagano A., Dhayade S., Athineos D., Caley M., Mannella V., Blyth K., Inman G.J., Leigh I.M.
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153671
Ximbio; 153671
Cell line databases/resources cancercelllines; CVCL_VJ53
Encyclopedic resources Wikidata; Q98129375
Gene expression databases GEO; GSM2611500
GEO; GSM2611501
GEO; GSM2611502
Polymorphism and mutation databases Cosmic; 2688666
Entry history
Entry creation07-Sep-2018
Last entry update30-Jan-2024
Version number11