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Cellosaurus SCCT11 (CVCL_VJ57)

[Text version]
Cell line name SCCT11
Synonyms SCC T11; T11
Accession CVCL_VJ57
Resource Identification Initiative To cite this cell line use: SCCT11 (RRID:CVCL_VJ57)
Comments Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Back, skin; UBERON=UBERON_0001068.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Asp132Val (c.395A>T); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 5173; HRAS; Simple; p.Lys170Arg (c.509A>G); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; 7882; NOTCH2; Simple; p.Glu1117Val (c.3350A>T); Zygosity=Unspecified (PubMed=24662767).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133817,19
D3S135814,16
D5S81811
D7S8207,12
D8S117911,15
D13S31711,12
D16S53912,13
D18S5111,13
D19S43312,14
D21S1129,30
FGA19,20
TH016,9.3
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=24662767; DOI=10.1038/jid.2014.154
South A.P., Purdie K.J., Watt S.A., Haldenby S., den Breems N.Y., Dimon M., Arron S.T., Kluk M.J., Aster J.C., McHugh A., Xue D.J., Dayal J.H.S., Robinson K.S., Rizvi S.M.H., Proby C.M., Harwood C.A., Leigh I.M.
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.
J. Invest. Dermatol. 134:2630-2638(2014)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1
Inman G.J., Wang J., Nagano A., Alexandrov L.B., Purdie K.J., Taylor R.G., Sherwood V., Thomson J., Hogan S., Spender L.C., South A.P., Stratton M.R., Chelala C., Harwood C.A., Proby C.M., Leigh I.M.
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428
Hassan S., Purdie K.J., Wang J., Harwood C.A., Proby C.M., Pourreyron C., Mladkova N., Nagano A., Dhayade S., Athineos D., Caley M., Mannella V., Blyth K., Inman G.J., Leigh I.M.
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153675
Ximbio; 153675
Encyclopedic resources Wikidata; Q98129389
Gene expression databases GEO; GSM2611485
GEO; GSM2611486
GEO; GSM2611487
Polymorphism and mutation databases Cosmic; 2688675
Entry history
Entry creation07-Sep-2018
Last entry update30-Jan-2024
Version number8