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Cellosaurus HL-60 blast (CVCL_VK43)

[Text version]
Cell line name HL-60 blast
Synonyms HL-60 Blast; HL-60_blast; HL60 blast
Accession CVCL_VK43
Resource Identification Initiative To cite this cell line use: HL-60 blast (RRID:CVCL_VK43)
Comments Population: Caucasian.
Characteristics: Subclone of HL-60 resistant to the growth and differentiation effects of various compounds.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (PubMed=10966170).
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=6945469; DOI=10.1016/0145-2126(81)90018-7
Major P.P., Griffin J.D., Minden M.D., Kufe D.W.
A blast subclone of the HL-60 human promyelocytic cell line.
Leuk. Res. 5:429-430(1981)

PubMed=10966170; DOI=10.1034/j.1600-0609.2000.90181.x
Aggerholm A., Gronbaek K., Guldberg P., Hokland P.
Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders.
Eur. J. Haematol. 65:109-113(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VK43
Encyclopedic resources Wikidata; Q94211458
Polymorphism and mutation databases Cosmic; 850383
Entry history
Entry creation07-Sep-2018
Last entry update05-Oct-2023
Version number12