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Cellosaurus BT474-LR (CVCL_VL01)

[Text version]

Cell line name BT474-LR
Synonyms BT474/LR; BT474 LR
Accession CVCL_VL01
Resource Identification Initiative To cite this cell line use: BT474-LR (RRID:CVCL_VL01)
Comments Selected for resistance to: ChEBI; CHEBI:49603; Lapatinib (Tykerb; Tyverb).
Sequence variations Heterozygous for MAPK1 p.His61Gln (c.183C>G) (from parent cell line).
Heterozygous for PIK3CA p.Lys111Asn (c.333G>C) (ClinVar=VCV000376483) (from parent cell line).
Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0179 (BT-474)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line

PubMed=25590338; DOI=10.4161/15384101.2014.994966
Canfield K., Li J., Wilkins O.M., Morrison M.M., Ung M., Wells W., Williams C.R., Liby K.T., Vullhorst D., Buonanno A., Hu H., Schiff R., Cook R.S., Kurokawa M.
Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.
Cell Cycle 14:648-655(2015)

Ontologies BTO; BTO:0006065
Other Wikidata; Q93432846
Entry history
Entry creation07-Sep-2018
Last entry update02-Jul-2020
Version number3