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Cellosaurus GM05823+hTERT (CVCL_VL10)

[Text version]
Cell line name GM05823+hTERT
Synonyms GM05823-hTert; hTERT+ GM05823
Accession CVCL_VL10
Resource Identification Initiative To cite this cell line use: GM05823+hTERT (RRID:CVCL_VL10)
Comments Transfected with: HGNC; 11730; TERT.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Leu2427_Arg2428del (c.7278_7283delCCTTAG); ClinVar=VCV000003020; Zygosity=Heterozygous (from parent cell line).
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7441 (AT5BI)
Sex of cell Male
Age at sampling 18Y
Category Telomerase immortalized cell line
Publications

PubMed=11313956; DOI=10.1038/sj.onc.1204072
Wood L.D., Halvorsen T.L., Dhar S., Baur J.A., Pandita R.K., Wright W.E., Hande M.P., Calaf G., Hei T.K., Levine F., Shay J.W., Wang J.J.Y., Pandita T.K.
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.
Oncogene 20:278-288(2001)

PubMed=21149446; DOI=10.1074/jbc.M110.204065
Kozlov S.V., Graham M.E., Jakob B., Tobias F., Kijas A.W., Tanuji M., Chen P., Robinson P.J., Taucher-Scholz G., Suzuki K., So S., Chen D., Lavin M.F.
Autophosphorylation and ATM activation: additional sites add to the complexity.
J. Biol. Chem. 286:9107-9119(2011)

Cross-references
Encyclopedic resources Wikidata; Q93789883
Entry history
Entry creation07-Sep-2018
Last entry update29-Jun-2023
Version number9