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Cellosaurus MYCN-3 Tet-on (CVCL_VL19)

[Text version]

Cell line name MYCN-3 Tet-on
Synonyms MYCN-3
Accession CVCL_VL19
Resource Identification Initiative To cite this cell line use: MYCN-3 Tet-on (RRID:CVCL_VL19)
Comments Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Transfected with: HGNC; 7559; MYCN.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with del 1-360).
Sequence variations Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0524 (SH-EP)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line

PubMed=15644444; DOI=10.1073/pnas.0405495102
Slack A., Chen Z., Tonelli R., Pule M., Hunt L., Pession A., Shohet J.M.
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
Proc. Natl. Acad. Sci. U.S.A. 102:731-736(2005)

Other Wikidata; Q95991617
Entry history
Entry creation07-Sep-2018
Last entry update20-May-2021
Version number4