ID   MYCN-3 Tet-on
AC   CVCL_VL19
SY   MYCN-3
DR   cancercelllines; CVCL_VL19
DR   Wikidata; Q95991617
RX   PubMed=15644444;
CC   Population: Caucasian.
CC   Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 7559; MYCN.
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0524 ! SH-EP
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 05-10-23; Version: 8
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RX   PubMed=15644444; DOI=10.1073/pnas.0405495102;
RA   Slack A., Chen Z.-W., Tonelli R., Pule M., Hunt L., Pession A.,
RA   Shohet J.M.;
RT   "The p53 regulatory gene MDM2 is a direct transcriptional target of
RT   MYCN in neuroblastoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:731-736(2005).
//