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Cellosaurus MB49-I (CVCL_VL62)

[Text version]
Cell line name MB49-I
Accession CVCL_VL62
Resource Identification Initiative To cite this cell line use: MB49-I (RRID:CVCL_VL62)
Comments Characteristics: Has an invasive and metastatic phenotype.
Characteristics: Established after 13 consecutive passages of MB49 through subcutaneous injection in the left flank of C57BL/6J male mice.
Karyotypic information: Has lost chromosome Y (PubMed=22559978).
Transformant: ChEBI; CHEBI:59032; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Disease Mouse bladder transitional cell carcinoma (NCIt: C25823)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/ICRF-a(t).
Hierarchy Parent: CVCL_7076 (MB49)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=19539312; DOI=10.1016/j.juro.2009.03.076
Lodillinsky C., Rodriguez V., Vauthay L., Sandes E., Casabe A., Eijan A.M.
Novel invasive orthotopic bladder cancer model with high cathepsin B activity resembling human bladder cancer.
J. Urol. 182:749-755(2009)

PubMed=22559978; DOI=10.1016/j.cancergen.2012.02.002
Fabris V.T., Lodillinsky C., Pampena M.B., Belgorosky D., Lanari C., Eijan A.M.
Cytogenetic characterization of the murine bladder cancer model MB49 and the derived invasive line MB49-I.
Cancer Genet. 205:168-176(2012)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=30867744; DOI=10.3892/ol.2019.9995
Alberto M., Cuello H.A., Gulino C.A., Pifano M., Belgorosky D., Gabri M.R., Eijan A.M., Segatori V.I.
Expression of bladder cancer-associated glycans in murine tumor cell lines.
Oncol. Lett. 17:3141-3150(2019)

Cross-references
Encyclopedic resources Wikidata; Q95985487
Entry history
Entry creation07-Sep-2018
Last entry update29-Jun-2023
Version number6