ID   OR6 [Human]
AC   CVCL_VN30
SY   OR-6
DR   BTO; BTO:0006069
DR   cancercelllines; CVCL_VN30
DR   Wikidata; Q98128353
RX   PubMed=15766575;
RX   PubMed=21320556;
CC   Population: Japanese.
CC   Characteristics: Transfected with ORN/C-5B/KE RNA, a construct containing renilla-type luciferase, neoR and genome-length HCV RNA from O strain (genotype 1b).
CC   Virology: Supports hepatitis C virus (HCV) replication.
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P27652; Renilla-type luciferase.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 30-01-24; Version: 11
//
RX   PubMed=15766575; DOI=10.1016/j.bbrc.2005.02.138;
RA   Ikeda M., Abe K.-i., Dansako H., Nakamura T., Naka K., Kato N.;
RT   "Efficient replication of a full-length hepatitis C virus genome,
RT   strain O, in cell culture, and development of a luciferase reporter
RT   system.";
RL   Biochem. Biophys. Res. Commun. 329:1350-1359(2005).
//
RX   PubMed=21320556; DOI=10.1016/j.virusres.2011.02.005;
RA   Mori K., Ikeda M., Ariumi Y., Dansako H., Wakita T., Kato N.;
RT   "Mechanism of action of ribavirin in a novel hepatitis C virus
RT   replication cell system.";
RL   Virus Res. 157:61-70(2011).
//