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Cellosaurus HEK293-HM3 (CVCL_VP06)

[Text version]

Cell line name HEK293-HM3
Synonyms HM3
Accession CVCL_VP06
Resource Identification Initiative To cite this cell line use: HEK293-HM3 (RRID:CVCL_VP06)
Comments Characteristics: Expresses the conditional kinase DeltaMEKK3:ER* which consist of the kinase domain of MAP3K3 fused in-frame to a modified form of the hormone binding domain of the estrogen receptor (ESR1) that can be de-repressed by 4-hydroxytamoxifen (4-HT) but not beta-estradiol.
Transfected with: HGNC; 3467; ESR1 (ligand-binding domain).
Transfected with: HGNC; 6855; MAP3K3 (kinase domain).
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line

PubMed=12444545; DOI=10.1038/sj.onc.1206000
Garner A.P., Weston C.R., Todd D.E., Balmanno K., Cook S.J.
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Oncogene 21:8089-8104(2002)

PubMed=14981547; DOI=10.1038/sj.onc.1207467
Todd D.E., Densham R.M., Molton S.A., Balmanno K., Newson C., Weston C.R., Garner A.P., Scott L., Cook S.J.
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest.
Oncogene 23:3284-3295(2004)

PubMed=16513653; DOI=10.1074/jbc.M510275200
Boughan P.K., Argent R.H., Body-Malapel M., Park J.-H., Ewings K.E., Bowie A.G., Ong S.J., Cook S.J., Sorensen O.E., Manzo B.A., Inohara N., Klein N.J., Nunez G., Atherton J.C., Bajaj-Elliott M.
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection.
J. Biol. Chem. 281:11637-11648(2006)

Cell line collections Ximbio; 153328
Other Wikidata; Q94095208
Entry history
Entry creation07-Sep-2018
Last entry update02-Jul-2020
Version number2