ID   HEK293-HM3
AC   CVCL_VP06
SY   HM3
DR   CancerTools; 153328
DR   Wikidata; Q94095208
DR   Ximbio; 153328
RX   PubMed=12444545;
RX   PubMed=14981547;
RX   PubMed=16513653;
CC   Characteristics: Expresses the conditional kinase DeltaMEKK3:ER* which consist of the kinase domain of MAP3K3 fused in frame to a modified form of the hormone binding domain of the estrogen receptor (ESR1) that can be de-repressed by 4-hydroxytamoxifen (4-HT) but not beta-estradiol.
CC   Transfected with: HGNC; 3467; ESR1 (ligand-binding domain).
CC   Transfected with: HGNC; 6855; MAP3K3 (kinase domain).
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0045 ! HEK293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 07-09-18; Last updated: 29-06-23; Version: 6
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RX   PubMed=12444545; DOI=10.1038/sj.onc.1206000;
RA   Garner A.P., Weston C.R., Todd D.E., Balmanno K., Cook S.J.;
RT   "Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell
RT   cycle arrest at the G2 checkpoint.";
RL   Oncogene 21:8089-8104(2002).
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RX   PubMed=14981547; DOI=10.1038/sj.onc.1207467;
RA   Todd D.E., Densham R.M., Molton S.A., Balmanno K., Newson C.,
RA   Weston C.R., Garner A.P., Scott L., Cook S.J.;
RT   "ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle
RT   arrest.";
RL   Oncogene 23:3284-3295(2004).
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RX   PubMed=16513653; DOI=10.1074/jbc.M510275200;
RA   Boughan P.K., Argent R.H., Body-Malapel M., Park J.-H., Ewings K.E.,
RA   Bowie A.G., Ong S.J., Cook S.J., Sorensen O.E., Manzo B.A.,
RA   Inohara N., Klein N.J., Nunez G., Atherton J.C., Bajaj-Elliott M.;
RT   "Nucleotide-binding oligomerization domain-1 and epidermal growth
RT   factor receptor: critical regulators of beta-defensins during
RT   Helicobacter pylori infection.";
RL   J. Biol. Chem. 281:11637-11648(2006).
//