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Cellosaurus HEK293-HR1 (CVCL_VP07)

[Text version]

Cell line name HEK293-HR1
Synonyms HR1
Accession CVCL_VP07
Resource Identification Initiative To cite this cell line use: HEK293-HR1 (RRID:CVCL_VP07)
Comments Characteristics: Expresses the conditional kinase DeltaRaf-1:ER* which consist of the kinase domain of ARAF fused in-frame to a modified form of the hormone binding domain of the estrogen receptor (ESR1) that can be de-repressed by 4-hydroxytamoxifen (4-HT) but not beta-estradiol.
Transfected with: HGNC; 646; ARAF (kinase domain).
Transfected with: HGNC; 3467; ESR1 (ligand-binding domain).
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=16513653; DOI=10.1074/jbc.M510275200
Boughan P.K., Argent R.H., Body-Malapel M., Park J.-H., Ewings K.E., Bowie A.G., Ong S.J., Cook S.J., Sorensen O.E., Manzo B.A., Inohara N., Klein N.J., Nunez G., Atherton J.C., Bajaj-Elliott M.
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection.
J. Biol. Chem. 281:11637-11648(2006)

Cross-references
Cell line collections Ximbio; 153329
Other Wikidata; Q94095223
Entry history
Entry creation07-Sep-2018
Last entry update02-Jul-2020
Version number2