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Cellosaurus CFBE41o- 6.2 WT-CFTR (CVCL_VP36)

[Text version]
Cell line name CFBE41o- 6.2 WT-CFTR
Accession CVCL_VP36
Resource Identification Initiative To cite this cell line use: CFBE41o- 6.2 WT-CFTR (RRID:CVCL_VP36)
Comments Transfected with: HGNC; 1884; CFTR.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pSVori-].
Caution: PubMed=18769032 describes two clones, CFBE41o- c7-6.2wt and CFBE41o- c10-6.2wt, but it is not possible to trace back which of the 2 clones is the one distributed as SCC160 (personal communication of Millipore).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations
  • Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Unspecified; Note=In the 2 genomic alleles while the transfected copies are wildtype (PubMed=18769032).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_HL93 (CFBE41o-)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO11
D3S135816,18
D5S81811,13
D7S8208,11
D8S117911,14
D13S3179,11
D16S53912
D18S5115,16
D21S1131.2
FGA22,24
Penta D12
Penta E12
TH019.3
TPOX8,9
vWA17

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Publications

PubMed=18769032; DOI=10.1159/000149783
Illek B., Maurisse R., Wahler L., Kunzelmann K., Fischer H., Gruenert D.C.
Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels.
Cell. Physiol. Biochem. 22:57-68(2008)

Cross-references
Cell line collections (Providers) Millipore; SCC160
Encyclopedic resources Wikidata; Q93447387
Entry history
Entry creation07-Sep-2018
Last entry update30-Jan-2024
Version number12