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Cellosaurus 786-M1B (CVCL_VR31)

[Text version]

Cell line name 786-M1B
Accession CVCL_VR31
Resource Identification Initiative To cite this cell line use: 786-M1B (RRID:CVCL_VR31)
Comments Characteristics: Established from lung metastatis in NOD/SCID mice which were intravenous inoculated with the parental cell line.
Sequence variations Homozygous for PTEN p.Gln149Ter (c.445C>T) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Heterozygous for TP53 c.560-2A>G; splice acceptor mutation and p.Pro278Ala (c.832C>G) (ClinVar=VCV000376645) (from parent cell line).
Homozygous for VHL p.Gly104fs*55 (c.311delG) (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=23223005; DOI=10.1038/nm.3029
Vanharanta S., Shu W., Brenet F., Hakimi A.A., Heguy A., Viale A., Reuter V.E., Hsieh J.J.-D., Scandura J.M., Massague J.
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Nat. Med. 19:50-56(2013)

Cross-references
Gene expression databases GEO; GSM800329
Other Wikidata; Q93309879
Entry history
Entry creation13-Nov-2018
Last entry update02-Jul-2020
Version number3