ID   786-M1B
AC   CVCL_VR31
DR   cancercelllines; CVCL_VR31
DR   GEO; GSM800329
DR   Wikidata; Q93309879
RX   PubMed=23223005;
CC   Population: Caucasian.
CC   Characteristics: Established from lung metastatis in NOD/SCID mice which were intravenous inoculated with the parental cell line.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1051 ! 786-O
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 10
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RX   PubMed=23223005; DOI=10.1038/nm.3029;
RA   Vanharanta S., Shu W.-P., Brenet F., Hakimi A.A., Heguy A., Viale A.J.,
RA   Reuter V.E., Hsieh J.J.-D., Scandura J.M., Massague J.;
RT   "Epigenetic expansion of VHL-HIF signal output drives multiorgan
RT   metastasis in renal cancer.";
RL   Nat. Med. 19:50-56(2013).
//