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Cellosaurus 786-M2B (CVCL_VR33)

[Text version]
Cell line name 786-M2B
Accession CVCL_VR33
Resource Identification Initiative To cite this cell line use: 786-M2B (RRID:CVCL_VR33)
Comments Population: Caucasian.
Characteristics: Established from lung metastatis in NOD/SCID mice which were intravenous inoculated with the parental cell line.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR30 (786-M1A)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,18
D3S135816
D5S8189
D7S82011,12
D8S117913
D13S3178
D16S53912
D18S5113,14
D19S43314,15
D21S1129,30
FGA24
TH016,9.3
TPOX8,11
vWA15,17

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Publications

PubMed=23223005; DOI=10.1038/nm.3029
Vanharanta S., Shu W.-P., Brenet F., Hakimi A.A., Heguy A., Viale A.J., Reuter V.E., Hsieh J.J.-D., Scandura J.M., Massague J.
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Nat. Med. 19:50-56(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VR33
Encyclopedic resources Wikidata; Q93309881
Gene expression databases GEO; GSM800331
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number10