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Cellosaurus MDA231-TGL (CVCL_VR35)

[Text version]
Cell line name MDA231-TGL
Synonyms MDA-231-HSV1-TK/GFP/Fluc; MDA-231-TGL; MDA 231-TGL
Accession CVCL_VR35
Resource Identification Initiative To cite this cell line use: MDA231-TGL (RRID:CVCL_VR35)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Caution: In PubMed=28283064 and the associated GEO data sets MDA234-TGL is termed MDA234 Parental.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Children:
CVCL_VR36 (MDA231-BrM2-831)CVCL_XB00 (MDA231-LeptoM)CVCL_DG21 (MDA231-LM2-4142)
CVCL_5998 (MDA231-LM2-4175)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO12,13
D1S165615,17
D2S44114,15
D2S133820,21
D3S135816
D5S81812
D7S8208
D8S117913
D10S124814,16
D12S39117
D13S31713
D16S53912
D18S5111,16
D19S43311
D21S1133.2
D22S104516
FGA22,23
Penta D14
Penta E11
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=16049480; DOI=10.1038/nature03799
Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W.-P., Giri D.D., Viale A.J., Olshen A.B., Gerald W.L., Massague J.
Genes that mediate breast cancer metastasis to lung.
Nature 436:518-524(2005)

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025
Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E., Massague J.
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VR35
Encyclopedic resources Wikidata; Q95987484
Gene expression databases GEO; GSM2194106
GEO; GSM2194107
GEO; GSM2194108
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number13