SY   MDA-231-HSV1-TK/GFP/Fluc; MDA-231-TGL; MDA 231-TGL
DR   GEO; GSM2194106
DR   GEO; GSM2194107
DR   GEO; GSM2194108
DR   Wikidata; Q95987484
RX   PubMed=16049480;
RX   PubMed=28283064;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Omics: Deep RNAseq analysis.
CC   Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
CC   Caution: In PubMed=28283064 and the associated GEO data sets MDA234-TGL is termed MDA234 Parental.
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D10S1248: 14,16
ST   D12S391: 17
ST   D13S317: 13
ST   D16S539: 12
ST   D18S51: 11,16
ST   D19S433: 11
ST   D1S1656: 15,17
ST   D21S11: 33.2
ST   D22S1045: 16
ST   D2S1338: 20,21
ST   D2S441: 14,15
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 8
ST   D8S1179: 13
ST   FGA: 22,23
ST   Penta D: 14
ST   Penta E: 11
ST   TH01: 7,9.3
ST   TPOX: 8,9
ST   vWA: 15
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 20-05-21; Version: 8
RX   PubMed=16049480; DOI=10.1038/nature03799;
RA   Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W., Giri D.D.,
RA   Viale A.J., Olshen A.B., Gerald W.L., Massague J.;
RT   "Genes that mediate breast cancer metastasis to lung.";
RL   Nature 436:518-524(2005).
RX   PubMed=28283064; DOI=10.1016/j.cell.2017.02.025;
RA   Boire A., Zou Y., Shieh J., Macalinao D.G., Pentsova E., Massague J.;
RT   "Complement component 3 adapts the cerebrospinal fluid for
RT   leptomeningeal metastasis.";
RL   Cell 168:1101-1113.e13(2017).