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Cellosaurus gMDCKI (CVCL_VR38)

[Text version]
Cell line name gMDCKI
Synonyms Genentech MDCKI
Accession CVCL_VR38
Resource Identification Initiative To cite this cell line use: gMDCKI (RRID:CVCL_VR38)
Comments Knockout cell: Method=CRISPR/Cas9; VGNC; 37431; ABCB1.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0592 (MDCK-I)
Children:
CVCL_VR39 (gMDCKI-MDR1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=30222362; DOI=10.1021/acs.molpharmaceut.8b00688
Chen E.C., Broccatelli F., Plise E., Chen B.-Y., Liu L.-L., Cheong J., Zhang S., Jorski J., Gaffney K., Umemoto K.K., Salphati L.
Evaluating the utility of canine Mdr1 knockout Madin-Darby canine kidney I cells in permeability screening and efflux substrate determination.
Mol. Pharm. 15:5103-5113(2018)

Cross-references
Encyclopedic resources Wikidata; Q93933959
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number9