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Cellosaurus MDCKII-LE (CVCL_VR40)

[Text version]
Cell line name MDCKII-LE
Synonyms MDCKII-Low Efflux; RRCK; Ralph Russ Canine Kidney
Accession CVCL_VR40
Resource Identification Initiative To cite this cell line use: MDCKII-LE (RRID:CVCL_VR40)
Comments Characteristics: Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=21766308; DOI=10.1002/jps.22674
Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y.-R., Federico J.J. III, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.
Development of a new permeability assay using low-efflux MDCKII cells.
J. Pharm. Sci. 100:4974-4985(2011)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4295481
ChEMBL-Targets; CHEMBL4296468
PubChem_Cell_line; CVCL_VR40
Encyclopedic resources Wikidata; Q95987829
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number7