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Cellosaurus MDCKII-LE (CVCL_VR40)

[Text version]

Cell line name MDCKII-LE
Synonyms MDCKII-Low Efflux; RRCK; Ralph Russ Canine Kidney
Accession CVCL_VR40
Resource Identification Initiative To cite this cell line use: MDCKII-LE (RRID:CVCL_VR40)
Comments Characteristics: Compared to parent cell line, has a lower expression of endogenous ABCB1/MDR1.
Derived from sampling site: Kidney.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=21766308; DOI=10.1002/jps.22674
Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y., Federico J.J. III, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.
Development of a new permeability assay using low-efflux MDCKII cells.
J. Pharm. Sci. 100:4974-4985(2011)

Cross-references
Other Wikidata; Q95987829
Entry history
Entry creation13-Nov-2018
Last entry update02-Jul-2020
Version number3